Thus, a previously unappreciated METTL3/YTHDF2/m6A-LINC01273 was identified in HCC cells with sorafenib resistance, and the regulatory loop between METTL3 and LINC01273 amplified the effect of LINC01273 in promoting sorafenib resistance. The gene discussed is METTL3; the disease is hepatocellular carcinoma.