Herein, we found that LINC01273 was located in the cytoplasm and prolonged the half-life of miR-600 by sequence complementation, resulting in miR-600 accumulation, accompanied by downregulation of METTL3 expression, a m6A ‘writer’ that enhances the sensitivity of HCC cells to sorafenib via regulation of autophagy [20]. Here, METTL3 is linked to hepatocellular carcinoma.