FANCA and cancer: DNA repair deficiency results in progressive bone marrow failure (BMF) and cancer susceptibility.[9] Most of inherited aplastic anemia (AA) cases are associated with DNA repair gene mutations, such as, dyskeratosis congenita (caused by mutations in RTEL1, DKC1, or hTERC)[10, 11, 12] and Fanconi anemia (FA) (caused by mutations in any of the 22 FA genes, but most commonly FANCA, FANCC and FANCG).