ADF was shown to significantly promote weight loss, glucose tolerance, and insulin sensitivity in diabetic mice.[10, 11] Clinical benefits in obese adults such as weight loss and cardio‐protection were also reported.[12] More importantly, Stekovic and colleagues[13, 14] reported that ADF could improve physiological and molecular markers of aging in healthy, nonobese humans, suggesting ADF as a short‐term safe and effective intervention for weight management and metabolic disease risk reduction. This evidence concerns the gene INS and metabolic disease.