It has been reported that the PI3Kγ/AKT signaling pathway in macrophages controlled the switch between immune stimulation and suppression in inflammation and cancer.[32] A recent study reported that PI3K/AKT signaling was required for IL‐4‐induced macrophage programming.[30] We detected higher AKT phosphorylation in animal models and patients (Figure S5A, B, Supporting Information). This evidence concerns the gene IL4 and cancer.