Translocation of CRTC2 into the nucleus triggers its activation and recruitment to cAMP‐responsive genes.[32] To characterize the molecular mechanisms by which CRTC2 promotes cystogenesis in ADPKD, we first analyzed the genome‐wide distribution of CRTC2 by chromatin immunoprecipitation coupled with sequencing (ChIP‐seq) in WT 9–12 human ADPKD cells. The gene discussed is CRTC2; the disease is autosomal dominant polycystic kidney disease.