Motif analysis of CRTC2‐binding peaks revealed that CRTC2 enriched in DNA‐binding motifs for CREB and other reported ADPKD‐associated transcriptional factors, including AP‐1,[55] TEAD,[56, 57] HIF‐1b,[58] and NF‐κB[59] (Figure 6h). This evidence concerns the gene NFKB1 and autosomal dominant polycystic kidney disease.