We next examined the expression of several CRTC2‐target genes in mouse kidneys from normal and ADPKD mice with or without Crtc2 knockout (Pkd1+/+Crtc2+/+, Pkd1+/+Crtc2−/−, Pkd1−/−Crtc2+/+, and Pkd1−/−Crtc2−/− mice) by performing RT‐qPCR assays. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.