CRTC2 and autosomal dominant polycystic kidney disease: As shown in Figure 5b–f and Figure S3a,b, Supporting Information, deletion of Crtc2 in the ADPKD setting caused decreases in kidney size, the ratio of kidney weight to body weight (KW/BW), cystic index, and blood urea nitrogen (BUN), suggesting that Crtc2 deletion alleviates cystogenesis and improves kidney function.