CRTC2 and autosomal dominant polycystic kidney disease: In contrast, NRF2 is downregulated and NRF2 condensates are lost in ADPKD.[65] In the current study, we find that CRTC2 translocates to nucleus and forms condensates in cystic cells, which now provides evidence that abnormal phase separation also occurs in ADPKD cells, and this first report for a renal disease further expands the spectrum of diseases associated with abnormal phase separation.