Pathway enrichment analysis revealed a remarkable enrichment for genes involved in cystogenesis‐associated pathways, such as metabolic pathways, cell adhesion, and extracellular exosome, as well as some known CRTC2‐regulated pathways, including insulin resistance and glucagon signaling pathway, which have also been reported to be perturbed in ADPKD[60, 61] (Figure 7e,f). The gene discussed is INS; the disease is autosomal dominant polycystic kidney disease.