We have previously reported that cAMP‐activated P‐TEFb promotes transcription elongation of cystogenesis‐associated genes by enhancing the release of paused Pol II at gene promoter‐proximal sites in ADPKD kidneys.[33] We then asked whether CRTC2 regulates Pol II pausing release in ADPKD cells. The gene discussed is CRTC2; the disease is autosomal dominant polycystic kidney disease.