Moreover, CD247, CD3G, HLA‐B, HLA‐C, and HLA‐F took part in various pathways, including Th1 and Th2 cell differentiation, PD‐L1 expression and PD‐1 checkpoint pathway in cancer, Th17 cell differentiation, antigen processing presentation, allograft rejection, and cell adhesion molecular (Figure 5I). The gene discussed is HLA-B; the disease is cancer.