In our study, using R package limma with statistical significance: adjusted p < 0.05 and |log2 fold change| > 1, 10 DEGs were identified, and all of them were downregulated in tumor adjacent compared with the normal tissues, of which eight DEGs (JUN, FOSB, FOS, ATF3, EGR1, IER2, ZFP36, and NR4A2) were overlapped with the original study mentioned above.19 The gene discussed is IER2; the disease is neoplasm.