SPG11 and hereditary spastic paraplegia: The brain MRI findings helped us to establish a robust clinical diagnosis of SPG11-HSP according to three characteristic findings, as follows: (i) a thin corpus callosum, (ii) atrophic changes in the frontotemporal lobes, and (iii) the ears of the lynx sign in the anterior horn of the lateral ventricles (Table 1 and Supplementary data) [6,7].