Patients with HSP type 11 (SPG11-HSP) have been reported to initially show progressive spastic paraplegia followed by additional symptoms such as cognitive decline, parkinsonism, psychosis, visual impairments, polyneuropathy, sphincter disturbance, and symptoms related to upper and lower motor neurons that resemble those of slowly progressive amyotrophic lateral sclerosis [3]. The gene discussed is SPG11; the disease is Mental deterioration.