ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: When hematopoietic stem cells (HSCs) acquire the transformative mutation known as the breakpoint cluster region gene-Abelson proto-oncogene (BCR-ABL) (Vuelta) due to genetic change occurring between chromosomes nine and 22 [23], the cells gain uncontrolled self-renewal ability and develop into leukemic stem cells (LSCs), which results in CML [22].