Low expression levels of ALDH8A1, ANGPTL6, ARG1, CPEB3, FAM110C, RGS5 and TAT were negatively associated with overall survival (OS) in HBV-associated HCC patients, and we observed that low expression levels of GNAL and MAGEA6 were positively associated with OS (Fig. 4). The gene discussed is RGS5; the disease is hepatocellular carcinoma.