Besides, Zhou et al. (2019) aimed to screen out the driver genes in smoking-associating lung adenocarcinoma via bioinformatics, and then they suggested that the seven genes (CYP17A1, PKHD1L1, RPE65, NTSR1, FETUB, IGFBP1 and G6PC) could be promising prognostic factors for lung adenocarcinoma according to their negative correlation with the patient survival. This evidence concerns the gene RPE65 and lung adenocarcinoma.