Besides, Zhou et al. (2019) aimed to screen out the driver genes in smoking-associating lung adenocarcinoma via bioinformatics, and then they suggested that the seven genes (CYP17A1, PKHD1L1, RPE65, NTSR1, FETUB, IGFBP1 and G6PC) could be promising prognostic factors for lung adenocarcinoma according to their negative correlation with the patient survival. Here, IGFBP1 is linked to lung adenocarcinoma.