Liu et al. (2018) reported the role of SF3B4 in promoting the proliferation and invasion of HCC cells. Miao confirmed the inhibitory effect of CPEB3 on HCC cell proliferation (Miao et al., 2020). Du et al. (2019) pointed out that ILF2 stimulates the malignant phenotype of HCC by stabilizing CREB. Here, CREB1 is linked to hepatocellular carcinoma.