In addition, innate features of NKp30+CD8+ T cells are accompanied by reduced expression of checkpoint inhibitor molecules,23 indicating that these cells might be less susceptible to inhibitory circuits in the tumor microenvironment.23 This NKp30+CD8+ T cell population is unlike other innate-like T cells previously described as dependent on HLA-E recognition.41–43 Indeed, we could show that NKp30+CD8+ T cells recognize and kill target cells deficient in B2M, which do not display HLA-E at the cell surface. This evidence concerns the gene HLA-E and neoplasm.