Based on the fact that Lnc-LSG1-induced ESRP2 ubiquitination promotes ESRP2 degradation and enhances ccRCC migration, we hypothesized that Arkadia and Lys27 of ESRP2 do not mediate the Lnc-LSG1 function. This evidence concerns the gene ESRP2 and nonpapillary renal cell carcinoma.