Further analysis of The Cancer Genome Atlas (TCGA) data revealed that ZFAS1 was upregulated in CRC among the six digestive system tumors esophageal carcinoma (ESCA), esophageal carcinoma (STAD), colon adenocarcinoma (COAD), cholangio carcinoma (CHOL), pancreatic adenocarcinoma (PAAD), and liver hepatocellular carcinoma (LIHC) (Figure 1B). This evidence concerns the gene ZFAS1 and carcinoma of esophagus.