,28 RNA immunoprecipitation (RIP) assays indicated that ZFAS1 enhanced PABP2 binding with SREBP1 mRNA, which stabilizes SREBP1 mRNA and augments transcription of SCD1 and FASN, finally leading to accelerated lipid accumulation and promotion of the malignant phenotype of colorectal cancer cells. This evidence concerns the gene SREBF1 and colorectal cancer.