Finally, we confirmed that knockdown of PABP2 and SREBP1 also impaired CRC cell proliferation as well as downregulation of ZFAS1, and rescue experiments confirmed that overexpression of SREBP1 could partially reverse the effect of ZFAS1 silencing on CRC cell lipogenesis and proliferation. This evidence concerns the gene PABPN1 and colorectal carcinoma.