In HPV‐unrelated HNSCC, also IS1 and IS5 were most prevalent, but in addition there was a large proportion of tumor (19%) with an IS2 signature (Intermediate immune cell infiltrate, immune suppressing phenotype with high TGF‐β signature; high IFN‐γ signature; high M1‐macrophage signature) (Table 1). This evidence concerns the gene TGFB1 and head and neck squamous cell carcinoma.