Immune hot with existing anti‐tumor response; high immune cell infiltrate with enrichments in CD4+ memory T‐cells, follicular T‐helper cells, CD8+ T‐cells and NK‐cells; elevated levels of M1‐M2 macrophage ratio and IFN‐γ; suppressed TGF‐β signature. The gene discussed is TGFB1; the disease is neoplasm.