For osteonecrosis of the femoral head, aberrant expression of CCND1 has been also found in the patients with osteonecrosis of the femoral head induced by systemic lupus erythematosus, and ESR1 may involve the osteonecrosis development of the children with acute lymphoblastic leukemia [22, 23]. The gene discussed is ESR1; the disease is systemic lupus erythematosus.