The levels of PCT, DD, TC, TG, LDL-C, HDL-C, and Hb in the two groups were similar, and the difference was not statistically significant (P > 0.05); IL-6, CRP, FIB, BNP, UA, Scr, WBC, and neutrophil count levels in the frailty syndrome group were higher than those in the nondebilitating syndrome group, and their ALB levels were lower than those in the nondebilitating syndrome group (P < 0.05). Here, CRP is linked to Down syndrome.