In conclusion, combined COPD, combined tumor, IL-6, BNP, UA, Scr, ALB, and neutrophil count are the influencing factors of elderly patients with coronary heart disease combined with frailty syndrome, and these factors can be used as the basis for the diagnosis of frailty syndrome and to guide the clinical development of targeted diagnosis and treatment plans. The gene discussed is IL6; the disease is chronic obstructive pulmonary disease.