As shown in Figure 4, compared with mice in the WT + control group and the WT + probiotic group, mice in the 3xTg-AD + control group had significantly increased level of Tau S202 in the cortex and hippocampus, and mice fed a probiotic-supplemented diet in the 3xTg-AD + probiotic group had a significantly reduced level of Tau S202 in the cortex and hippocampus (P < 0.05). The gene discussed is MAPT; the disease is Alzheimer disease.