RPS6KB1 and non-small cell lung carcinoma: To explore the activation of the mTORC1 signaling pathway in the NSCLC tissues and normal tissues, immunohistochemistry was operated, and the representative results showed that the cancerous tissues expressed higher levels of p-mTOR, p-S6K1, and p-4EBP in comparison to normal tissues which indicated that the mTORC1 pathway was activated in NSCLC (Figure 3(a)).