To evaluate the expression level of LDLRAD3 in 30 NSCLC tissues (I + II, n = 16; III + IV, n = 14) and paired normal tissues (n = 30), qRT-PCR was performed, and it was shown that its expression level was higher in cancerous tissues compared with the corresponding tumor-adjacent normal tissues (P < 0.01) and the higher level of LDLRAD3 was detected in the cancerous tissues of III + IV grades compared with I + II grades (P < 0.01) (Figure 1(a)). The gene discussed is LDLRAD3; the disease is neoplasm.