In the present study, we identified that miR-20a-5p was targeted by LDLRAD3 and it was also complimentary with SLC7A5 to reduce its expression to show the tumor-regulatory roles of the LDLRAD3-miR-20a-5p-SLC7A5 axis, such as the control of cell proliferation, migration, and invasion of A549 and H1299 cells. Here, SLC7A5 is linked to neoplasm.