TNF and hypertensive disorder: TLR2, IL1-β, IL-6, and TNF-ɑ levels in serum of mice with hypertension combined with hyperlipidemia also significantly increased (n = 5, all P < 0.001, Figure 1(c)), but there was no obvious difference in CCL2 (n = 5, P > 0.05, Figure 1(c)).