Figure 1 shows that our bladder cancer subnetwork encodes the cancer hallmark capabilities of: sustaining chronic proliferation (G2M checkpoints, E2F targets and P53 pathway hallmark signatures), resisting cell death (apoptosis signature), and activating invasion and migration (TNFA signalling via NFkB); which are also associated with the deregulation of cell cycle generally observed in cancers. This evidence concerns the gene TP53 and cancer.