Further confidence in our bladder cancer subnetwork comes from the observation that most of the proteins in it participate in several biological processes relevant to bladder cancer such as pathways associated with chromatin modification and myogenesis—a phenomenon associated with muscle invasive bladder cancer—and bladder cancer hallmark signatures (G2M-checkpoint, apoptosis and invasion and metastasis signalling through P53 and Wnt). This evidence concerns the gene TP53 and urinary bladder carcinoma.