AKT1 and osteoporosis: Then, AKT-PIP3 interaction, through the interdomain conformational change-induced AKT for open conformer, exposes Thr308 and Ser473 subsequent phosphorylation of phosphoinositide-dependent protein kinase, and phosphorylation of Thr308 and Ser473 fully activated AKT, which through the phosphorylation of the downstream kinases, participate in a variety of regulating cell proliferation and growth, and it also has played an important role in many fields such as cancer [15], angiogenesis [16], and osteoporosis [17].