SPAG5 and triple-A syndrome: There were 43 genes (CPS1, KYNU, FANCD2, LAMA2, ARHGAP15, UPB1, ITGAX, TDO2, FKBP5, ARRDC4, TIAM1, RBM7, PEG3, IGFBP3, IBSP, SGCA, COQ2, MFGE8, SPAG5, NPTX2, OTOA, HYAL1, IER5, FMNL1, SULT1A1, HNRNPC, BTG1, LSP1, TMEM100, WDYHV1, PTPN2, SCRG1, TMPO, TPM2, GABRR1, FAM53B, AIF1, GRK5, FYCO1, SLC26A3, RGS5, AGT, and FAT3) in both of the human AAA group and SIRT6-KO mouse group, which met the following criteria: (1) logarithmic value  | log2FC | >1 and adjusted P value < 0.05 and (2) existing in the SIRT6-KO mouse group and existing in at least 1 human AAA group.