NPTX2 is a potential target for cognitive dysfunction of Alzheimer's disease and other nervous system disease based on the previous study [35], and it is reported that SCRG1 is involved in cell growth suppression and differentiation during DEX-dependent chondrogenesis [36], but it lacks the evidence of significant association between VSMCs and NPTX2 or SCRG1 yet. Here, NPTX2 is linked to Alzheimer disease.