GRK5 and triple-A syndrome: There were top 5 DEGs (KYNU, NPTX2, SCRG1, GRK5, and RGS5) in both of the human AAA group and SIRT6-KO mouse group (Figure 2), which met the following criteria: (1) logarithmic value  | log2FC | >1 and adjusted P value < 0.05 and (2) existing in the SIRT6-KO mouse group and existing in at least 3 human AAA groups.