ESR1 and hepatocellular carcinoma: In addition, a total of 12 overlapping genes (HAMP, TSLP, ESR1, KLKB1, FOS, ECM1, TBXA2R, CD5L, CCL14, DNASE1L3, CRHBP, and CCL23) among HCC-related genes, DEGs, and IFRGs were identified as crucial IFRGs in HCC (Figure 2(c), Table 1).