Patients with metastatic colorectal cancer are often eligible for palliative chemotherapy, consisting of a combination of 5-fluorouracil, oxaliplatin, irinotecan, antibodies against epidermal growth factor receptor (EGFR) and/or vascular endothelial growth factor (VEGF), and regorafenib [7]. The gene discussed is VEGFA; the disease is metastatic colorectal cancer.