TNF and injury: Relevant studies have shown that VAC technology features various advantages, such as promoting drainage of wound exudate and reducing bacterial culture medium in the wound, thus improving inflammatory response of patients on the wound.22 As shown in the results of this study, patients with severe hand trauma treated with VAC combined with multiple flaps have lower levels of IL-8, TNF and LPS, indicating that the application of VAC combined with multiple flaps can significantly reduce the inflammatory response of patients.