The laboratory investigation showed that, after CD4+ T lymphocytes in the mice were removed, CD3+ T lymphocytes increased, and more than a half of mice showed the features of vitiligo.16,17 The Chinese investigator Jiang Yu found that the immunity of patients with generalized vitiligo was low, CD4+ T lymphocyte declined, and CD8+ T lymphocyte rose. Here, CD4 is linked to vitiligo.