CRP and Sepsis: Those hospitals who used this for more than three years showed reduced mortality by 36%.24 If the time limits to three hours, further improved the survival in cost effective manner.25 An update in 2018 by Levy suggests, more aggressive management by one hour.26 However adopting to one hour bundle is a concern, leads to more pressure on emergency department with over treatment of patients among sepsis without shock.22 Procalcitonin and C-Reactive proteins are non-specific markers.