TNF and heart failure: For example, surgical operations will further aggravate coronary artery intima injury, causing micro-embolism, secondary inflammatory reactions and other reactions15, and inflammation cytokines (IL-6, CRP, TNF-α, etc.)gathered around the stent may lead to local inflammation and aggravate a series of cardiovascular events such as heart failure, arrhythmia, and restenosis after stent.16