At the same time, impaired liver function causes inactivation of liver glycogen synthase, hexokinase, glucokinase, growth hormone, and other obstacles, thereby leading to an abnormal glycogen synthesis and the increased gluconeogenesis (Kumar, 2018); (II) The decreased hepatic insulin clearance may result in peripheral hyperinsulinemia, because the liver function in patients with liver cirrhosis reduces and portosystemic shunts increase. This evidence concerns the gene INS and cirrhosis of liver.