Besides slowing tumor growth, KD sensitizes tumor cells to classic chemotherapy or radiotherapy in neuroblastoma, glioma, and lung cancer.243–246 For example, the KD supplemented with medium-chain TG enhanced the antitumor and anti-angiogenic efficacy of chemotherapy on neuroblastoma xenografts in a CD1-nu mouse model.247 In addition, KD showed promising benefits in boosting the effect of anti-PD-1/PD-L1 immunotherapy. The gene discussed is CD274; the disease is neuroblastoma.