LAMB2 and coloboma: Knockdown of bmpr1ba (Figure 2D; 85% with coloboma penetrance, n = 13), bmpr1bb (Figure 2E; 80% penetrance, n = 23), or double bmpr1ba/bb (Figure 2F; 1 pmol of each MO per embryo, 91% penetrance, n = 21) showed a penetrant coloboma covering the whole ventral retina assessed by the expression of laminin remaining along the whole proximal-distal axis of the OF.