Measurements of serum tumor markers showed elevated level of cytokeratin 19 fragment (Cyfra21-1: 4.77 ng/mL, reference: ≤ 3.3 ng/mL), neuron-specific enolase (NSE: 19.60 ng/mL, reference: ≤ 15.2 ng/mL), and squamous cell carcinoma antigen (SCCA: 2.58 ng/mL, reference: ≤ 2.5 ng/mL). The gene discussed is ENO2; the disease is neoplasm.