Our data revealed that inhibition of circ_0071269 significantly improved cell viability, LDH content, IL-1β and IL-18 content, apoptosis rate, and protein levels of NLRP3 and caspase-1, which demonstrated that pyroptosis of DCM model cells were suppressed by konckdown of circ_0071269. Here, CASP1 is linked to familial dilated cardiomyopathy.