DEK and cancer: 55 The DEK (human chromatin protein) is phosphorylated by the protein kinase CK2.56 Acetylation of DEK affects the sub-nuclear localization and the ability to bind DNA.57 Fbxw7 acts as a tumor suppressor targeting multiple transcriptional activators and may target DEK for degradation to influence murine intestinal homeostasis and cancer by DEK ubiquitination.58 The intricate network of phosphorylation, acetylation, and ubiquitination mediated plant immunity had been reported.