Moreover, flow cytometry analysis revealed that overexpression of ADORA2A-AS1 inhibited cell apoptosis, while miR-665 mimic promoted cell apoptosis and also reversed anti-apoptotic effect of ADORA2A-AS1 overexpression in CML cells (Figure 5(c)). This evidence concerns the gene ADORA2A and chronic myelogenous leukemia, BCR-ABL1 positive.