Masson staining showed that compared with the oe-NC group, myocardial fibrosis was aggravated in the oe-Smurf1 + oe-NC group, and the proportion of the myocardial tissue fibrosis area (blue area) to the myocardial surface area (red area) was reduced and the degree of myocardial fibrosis was decreased in the oe-NC + oe-PTEN group; The degree of myocardial tissue fibrosis in the oe-Smurf1 + oe-PTEN group was significantly decreased compared with the oe-Smurf1 + oe-NC group (Figure 6(e)). Here, SMURF1 is linked to Myocardial fibrosis.