The subsequent experimental results showed that when Smurf1 and PTEN were overexpressed simultaneously, PTEN was increased in rats, ventricular hypertrophy, pulmonary edema, and the myocardial structure were improved, fibrosis of myocardial tissue in rats was decreased, and oxidative stress was significantly relieved. The gene discussed is SMURF1; the disease is Ventricular hypertrophy.