RELN and hepatocellular carcinoma: To analyze the role of the RELN gene in sorafenib-resistant HCC cells, we analyzed the drug gene interaction database (https://dgidb.genome.wustl.edu/search_interactions) and found that there was no interaction between RELN gene and sorafenib (Supplementary Table 6), so we believed that RELN was not a direct target of sorafenib.