For the ulcerative colitis cohort, 21 terms were enriched in the molecular function GO namespace including calcium ion binding (GO:0005509), peptidase activity (acting on L-amino acid peptides) (GO:0008233), lipid binding (GO:0008289), catalytic activity (acting on a protein) (GO:0140096), serine-type endopeptidase activity (GO:0004252), serine hydrolase activity (GO:0017171), and calcium-dependent phospholipid binding (GO:0005544) (p < 0.001, odds ratio >10) [see Additional File 5]. The gene discussed is LAP3; the disease is ulcerative colitis.