This finding shifts the current paradigm that depicts PHF20 and PHF20L1 in the same NSL species and has potential important implications for a differential role of PHF20 and PHF20L1 in regulating NSL functions both in physiological conditions and in disease, such as cancer, where both PHFs have been shown to be altered (25, 26, 27, 28, 37, 38). The gene discussed is PHF20; the disease is cancer.