In the tumor microenvironment, the interaction of PtdSer (exposed on cancer cells or tumor-derived exosomes) and PtdSer receptors (such as TIM-3 and TAM) expressed on immune cells can trigger a precisely-controlled-immunosuppressive pathway to weaken the innate and adaptive immune response and ultimately promote immune escape [19–21]. This evidence concerns the gene HAVCR2 and neoplasm.