LDLR levels have been reported to be elevated in prostate cancer, especially metastatic disease [49] but a recent study reported that the scavenger receptor B1 (SR-B1, encoded by SCARB1), which rather acts as a receptor for high-density lipoproteins (HDL), and not LDLR is upregulated [50]. This evidence concerns the gene LDLR and metastatic neoplasm.