In this population-based retrospective cohort study, Cre/BW ratio was found to be negatively associated with the incidence of T2DM, independent of age, sex, height, FPG, SBP, DBP, TC, TG, LDL, HDL-C, BUN, AST, ALT, drinking status, smoking status, and family history of diabetes. This evidence concerns the gene GPT and diabetes mellitus.