After an average follow-up of 3.13 ± 0.94 years, 4001(1.99%) participants developed T2DM Participants in the highest group of Cre/BW ratio (Q4) had lower weight, BMI, SBP, DBP, TC, TG, FPG, LDL, ALT, AST, and consisted of more males and drinkers than for the other groups (Q1-3). The gene discussed is GPT; the disease is type 2 diabetes mellitus.