PKM and pulmonary arterial hypertension: Abnormal glycolysis is also a typical characteristic of PAH, and one study suggested that decreased microRNA-124 cause dysregulation of glycolysis by elevating the expression of polypyrimidine tract binding protein (PTBP1) and pyruvate kinase M2 (PKM2) in Sugen5416 and hypoxia-induced PAH rats [134].