Moreover, the positive immunoreactivity of nuclear NF-κB was significantly associated with lymph node metastasis (χ2 = 16.911, P < 0.001) and tumor-node-metastasis (TNM) stage III-IV (χ2 = 22.707, P < 0.001) as shown in Table 1. The gene discussed is NFKB1; the disease is metastasis.