High level of CD68 was just related to lymph node metastasis (χ2 = 4.076; P = 0.044) and tumor-node-metastasis (TNM) stage III-IV (χ2 = 5.871; P = 0.015), while CD80 was not associated with clinicopathological characteristics (Table 1). This evidence concerns the gene CD80 and metastatic malignant neoplasm in the lymph nodes.