The numbers of Granulysin + IFN-γ + Vγ2 T effectors upon BCG-Nanocage/IL2 co-stimulation showed similar results with those of BCG/IL2 co-stimulation (Fig. 3E–F), further suggested the reserved ability of BCG-Nanocage to induce anti-TB protective cytokines/cytotoxic molecules production in Vγ2 T cells. This evidence concerns the gene IL2 and tuberculosis.