Woo et al. examined the onset of pre-metastasis in patients with HCC by sequencing miRNAs in tumor-derived exosomes and found that some miRNAs like miR-1307-5p could enhance the epithelial-to-mesenchymal transition (EMT) process through downregulation of SEC14 like lipid-binding 2 (SEC14L2) and Endoglin (ENG) genes, therefore miR-1307-5p can be used as a predictive biomarker for HCC metastasis [104]. Here, ENG is linked to neoplasm.