TTR and malnutrition: Pre-albumin, also known as transthyretin, is synthesized by the liver and regulates vitamin A and thyroxine synthesis and transportation [8].Given that the half-life of pre-albumin is only about two days, it can reflect minor changes caused by malnutrition and liver insufficiency in a short period [12, 25].Fibrinogen has been reported to be involved in the formation of the inflammatory microenvironment, inflammatory level, angiogenesis, malignant tumor cell proliferation, invasion, and metastasis as an important inflammatory factor [26].