We analyzed the gene mutations of TOP2A and CNAs in the samples of HCA in 8 databases using the cBioPortal database, and the results showed that there were 8 mutation sites in the TOP2A gene (Fig. 8B), and that TOP2A had different mutation frequencies in different data sets, 2.12% (TCGA, Firehose Legacy), 1.88% (TCGA, PanCance Atlas), and 0.43% AMC, Hepatology 2014), 0.41% (INSERM, Nat Genet 2015), TCGA data analysis shows that HCA patients have the largest number of TOP2A CNAs, mainly due to genetic mutations, about 0.5%-1% (Fig. 8A). The gene discussed is TOP2A; the disease is hepatocellular adenoma.