Based on a comprehensive expression analysis and survival analysis, 19 genes (ASPM, CCNA2, CDCA2, FAM83D, KIF2C, KIF20A, MCM2, MCM6, PRC1, TK1, TPX2, TROAP, AURKA, CDC20, CENPF, HJURP, KIF4A, MCM5, MELK, NCAPG, PTTG1, TOP2A, TRIP13 and UBE2T as a key gene that may be associated with HCC progression. This evidence concerns the gene CDCA2 and hepatocellular carcinoma.