Our data show that TOP2A in patients with hepatocellular carcinoma (HCC) is the expression of tumor tissue is high expression in normal tissue, the experiment of immunohistochemical results also prove the conclusion, especially in the liver cell cancer III midterm highest expression, show TOP2A in the mid-late hepatocellular carcinoma (HCC) has potential application value in the diagnosis. The gene discussed is TOP2A; the disease is neoplasm.