SHC4 and hepatocellular carcinoma: Consistent with the IHC analysis, SHC4 was highly expressed in most of the HCC samples (104/13,875.4%) (Additional file 1: Fig. S1A), and SHC4 was significantly higher in HCCs compared with their adjacent normal tissues (P < 0.0001, Additional file 1: Fig. S1B, C).